Lauren Haque

Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity

Hua Gong, David S. Weinstein, Zhonghui Lu et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 38 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors

James J.‐W. Duan, Zhonghui Lu, Bin Jiang et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 30 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +10

Discovery and Structure–Activity Relationship (SAR) of a Series of Ethanolamine-Based Direct-Acting Agonists of Sphingosine-1-phosphate (S1P₁)

John L. Gilmore, James E. Sheppeck, Scott H. Watterson et al. · Journal of Medicinal Chemistry · 2016 · 24 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +11

Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists

Jun Shi, Zhengxiang Gu, Elizabeth A. Jurica et al. · Journal of Medicinal Chemistry · 2018 · 24 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

David Williams, Jay A. Markwalder, Aaron Balog et al. · Bioorganic & Medicinal Chemistry Letters · 2018 · 17 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +9