Hua Gong

Discovery of 6-Fluoro-5-(<i>R</i>)-(3-(<i>S</i>)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4<i>H</i>)-yl)-2-methylphenyl)-2-(<i>S</i>)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1<i>H</i>-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers

Scott H. Watterson, George V. De Lucca, Qing Shi et al. · Journal of Medicinal Chemistry · 2016 · 142 citations · Full text

Azaxanthene Based Selective Glucocorticoid Receptor Modulators: Design, Synthesis, and Pharmacological Evaluation of (<i>S</i>)-4-(5-(1-((1,3,4-Thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5<i>H</i>-chromeno[2,3-<i>b</i>]pyridin-2-yl)-2-fluoro-<i>N</i>,<i>N</i>-dimethylbenzamide (BMS-776532) and Its Methylene Homologue (BMS-791826)

David S. Weinstein, Hua Gong, Arthur M. Doweyko et al. · Journal of Medicinal Chemistry · 2011 · 55 citations · Full text

Immunology, Whole Blood, Pharmacotherapy +20

Identification of bicyclic hexafluoroisopropyl alcohol sulfonamides as retinoic acid receptor-related orphan receptor gamma (RORγ/RORc) inverse agonists. Employing structure-based drug design to improve pregnane X receptor (PXR) selectivity

Hua Gong, David S. Weinstein, Zhonghui Lu et al. · Bioorganic & Medicinal Chemistry Letters · 2017 · 38 citations · Full text

Molecular Pharmacology, Pregnane X Receptor, Biochemistry +10

Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists

Bingwei Yang, David S. Weinstein, Lidia M. Doweyko et al. · Journal of Medicinal Chemistry · 2010 · 37 citations · Full text

Sar Exploration, Medicinal Chemistry, Biochemistry +14

Synthesis of the Shark Repellent Pavoninin-4

John R. Williams, Hua Gong, Nathan Hoff et al. · The Journal of Organic Chemistry · 2005 · 28 citations

Combinatorial Chemistry, Diversity Oriented Synthesis, Biosynthesis +15