Zhonghui Lu

Discovery of γ-Lactam Hydroxamic Acids as Selective Inhibitors of Tumor Necrosis Factor α Converting Enzyme:  Design, Synthesis, and Structure−Activity Relationships

James J.‐W. Duan, Lihua Chen, Zelda R. Wasserman et al. · Journal of Medicinal Chemistry · 2002 · 119 citations · Full text

Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-α converting enzyme (TACE): Discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1′ substituents

Zhonghui Lu, Gregory R. Ott, Rajan Anand et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 56 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +11

Discovery of low nanomolar non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)

James J.‐W. Duan, Lihua Chen, Zhonghui Lu et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 53 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Drug Targeting +9

Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists

James J.‐W. Duan, Zhonghui Lu, Bin Jiang et al. · ACS Medicinal Chemistry Letters · 2019 · 52 citations · Full text

Potent, exceptionally selective, orally bioavailable inhibitors of TNF-α Converting Enzyme (TACE): Novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1′ substituents

Gregory R. Ott, Naoyuki Asakawa, Zhonghui Lu et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 46 citations · Full text

Medicinal Chemistry, Pharmaceutical Science, Biochemistry +11