Concepedia

Receptor Binding Optimization

Receptor Binding Optimization is a computational or experimental methodology in medicinal chemistry that systematically enhances the affinity and selectivity of ligand-receptor interactions by strategically modifying molecular structures, particularly through the strategic incorporation of nonclassical bioisosteres to improve pharmacodynamic and physicochemical properties.

1K

Publications

38.9K

Citations

7.6K

Authors

1K

Institutions

Publications per year

2017–2026

162

Parents

Publications

1K

Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation

Gareth Jones, Peter Willett, Robert C. Glen · Journal of Molecular Biology · 1995 · 1.5K citations

, , +15

Design of amidobenzimidazole STING receptor agonists with systemic activity

Joshi M. Ramanjulu, G. Scott Pesiridis, Jingsong Yang et al. · Nature · 2018 · 865 citations

, , +10

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

Longxing Cao, Inna Goreshnik, Brian Coventry et al. · Science · 2020 · 718 citations · Full text

, , +17

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

Martine Clozel, Volker Breu, Gillian A. Gray et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 668 citations

, , +15

Mammalian cell–based optimization of the biarsenical-binding tetracysteine motif for improved fluorescence and affinity

Brent R. Martin, Ben N. G. Giepmans, Stephen Adams et al. · Nature Biotechnology · 2005 · 424 citations

, , +12

1–5 of 1K

Authors

7.6K

  1. BW
    Bernhard Wünsch

    University of Münster, Germany

    15 publications · 406 citations

    12

    h-index

  2. DS
    Dirk Schepmann

    University of Münster, Germany

    12 publications · 345 citations

    11

    h-index

  3. FV
    Flavia Varano

    University of Florence, Italy

    10 publications · 322 citations

    10

    h-index

  4. ZL
    Zheng Li

    China Pharmaceutical University, China

    10 publications · 240 citations

    10

    h-index

  5. MT
    Masaaki Toda

    Ono Pharmaceutical (Japan), Japan

    10 publications · 214 citations

    10

    h-index

1–5 of 7.6K

Institutions

1K

  1. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    20 h-index

    433 publications

    13.7K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    19 h-index

    89 publications

    3.4K citations

  3. GlaxoSmithKline (United States)

    Philadelphia, United States

    17 h-index

    276 publications

    43.3K citations

  4. United States Military Academy

    West Point, United States

    17 h-index

    204 publications

    6.4K citations

  5. Inserm

    Paris, France

    16 h-index

    89 publications

    4K citations

  6. Bristol-Myers Squibb (United States)

    New York, United States

    16 h-index

    344 publications

    12.5K citations

  7. Amgen (United States)

    Thousand Oaks, United States

    16 h-index

    249 publications

    9K citations

  8. Takeda (Japan)

    Osaka, Japan

    15 h-index

    198 publications

    6.2K citations

1–8 of 1K

Venues

  1. Journal of Medicinal Chemistry

    179 publications · 9.2K citations

    54

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    309 publications · 8K citations

    39

    h-index

  3. Bioorganic & Medicinal Chemistry

    134 publications · 3.7K citations

    33

    h-index

  4. European Journal of Medicinal Chemistry

    101 publications · 2.9K citations

    31

    h-index

  5. ACS Medicinal Chemistry Letters

    25 publications · 786 citations

    17

    h-index

1–5