Concepedia

Nonclassical Bioisosteres

Nonclassical Bioisosteres is a class of bioisosteric replacements that, unlike classical bioisosteres, do not preserve atom number, size, or valence-electron configuration of the original functional group but nonetheless reproduce its essential steric, electronic, or pharmacophoric features so as to maintain similar biological activity at the target.

41

Publications

1.7K

Citations

233

Authors

81

Institutions

Publications per year

2017–2026

7

Variants

Non-classical Bioisosteres

Parents

Children

Publications

41

Antibacterial chalcones––bioisosteric replacement of the 4′-hydroxy group

Simon Feldbæk Nielsen, Thomas Boesen, Mogens Larsen et al. · Bioorganic & Medicinal Chemistry · 2004 · 182 citations

, , +12

General access to cubanes as benzene bioisosteres

Mario P. Wiesenfeldt, James A. Rossi‐Ashton, Ian B. Perry et al. · Nature · 2023 · 156 citations · Full text

, , +13

Nonclassical Phenyl Bioisosteres as Effective Replacements in a Series of Novel Open-Source Antimalarials

Edwin G. Tse, Sevan D. Houston, Craig M. Williams et al. · Journal of Medicinal Chemistry · 2020 · 149 citations · Full text

, , +17

Providing a New Aniline Bioisostere through the Photochemical Production of 1-Aminonorbornanes

Daryl Staveness, Taylor Sodano, Kangjun Li et al. · Chem · 2018 · 89 citations · Full text

, , +11

Oxadiazoles as bioisosteric transformations of carboxylic functionalities. II

Knud Erik Andersen, B. F. LUNDT, A.S. Jørgensen · European Journal of Medicinal Chemistry · 1996 · 80 citations

, , +14

1–5 of 41

Authors

233

  1. MM
    Maria Michela Corsaro

    University of Naples Federico II, Italy

    2 publications · 78 citations

    2

    h-index

  2. JG
    Jan Gross

    Goethe University Frankfurt, Germany

    2 publications · 56 citations

    2

    h-index

  3. RT
    Reinhold Tacke

    University of Würzburg, Germany

    2 publications · 56 citations

    2

    h-index

  4. EM
    E. Mutschler

    Goethe University Frankfurt, Germany

    2 publications · 56 citations

    2

    h-index

  5. BK
    Burkhard Klenke

    Christian-Albrechts-Universität zu Kiel, Germany

    2 publications · 30 citations

    2

    h-index

1–5 of 233

Institutions

81

  1. University of Naples Federico II

    Naples, Italy

    2 h-index

    8 publications

    318 citations

  2. Christian-Albrechts-Universität zu Kiel

    Kiel, Germany

    2 h-index

    4 publications

    60 citations

  3. Novo Nordisk (Denmark)

    Copenhagen, Denmark

    2 h-index

    6 publications

    387 citations

  4. Pfizer (United States)

    New York, United States

    2 h-index

    6 publications

    543 citations

  5. Zayed University

    Abu Dhabi, United Arab Emirates

    2 h-index

    2 publications

    27 citations

  6. University of Würzburg

    Würzburg, Germany

    2 h-index

    14 publications

    382 citations

  7. University of Basilicata

    Potenza, Italy

    2 h-index

    2 publications

    78 citations

  8. United States Military Academy

    West Point, United States

    1 h-index

    1 publications

    12 citations

1–8 of 81

Venues

  1. Bioorganic & Medicinal Chemistry Letters

    6 publications · 117 citations

    6

    h-index

  2. European Journal of Medicinal Chemistry

    5 publications · 203 citations

    5

    h-index

  3. Phytochemistry

    3 publications · 149 citations

    3

    h-index

  4. Bioorganic & Medicinal Chemistry

    3 publications · 255 citations

    3

    h-index

  5. Future Medicinal Chemistry

    FMC · 2 publications · 27 citations

    2

    h-index

1–5