Synthesis and Biological Evaluation of a New Set of Pyrazolo[1,5-<i>c</i>]quinazoline-2-carboxylates as Novel Excitatory Amino Acid Antagonists

Flavia Varano, Daniela Catarzi, Vittoria Colotta, +4

Journal of Medicinal Chemistry

1,2,4-Triazolo[4,3-<i>a</i>]quinoxalin-1-one Moiety as an Attractive Scaffold To Develop New Potent and Selective Human A₃ Adenosine Receptor Antagonists:  Synthesis, Pharmacological, and Ligand−Receptor Modeling Studies

Vittoria Colotta, Daniela Catarzi, Flavia Varano, +7

Journal of Medicinal Chemistry

Adenosine ReceptorsAttractive ScaffoldReceptor AntagonistsAdenosine Receptor AntagonistsPharmacotherapy +14

Synthesis and Structure−Activity Relationships of a New Set of 2-Arylpyrazolo[3,4-<i>c</i>]quinoline Derivatives as Adenosine Receptor Antagonists

Vittoria Colotta, Daniela Catarzi, Flavia Varano, +5

Journal of Medicinal Chemistry

Adenosine ReceptorsAdenosine Receptor AntagonistsOrganic ChemistryPharmacotherapyHeterocycle Chemistry +18

1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: Synthesis, biological evaluation, and molecular modeling study

Flavia Varano, Daniela Catarzi, Vittoria Colotta, +7

Bioorganic & Medicinal Chemistry

Molecular PharmacologyMolecular Modeling StudyBiochemistryMedicineRational Drug Design +8

Inhibition of A2A Adenosine Receptor Signaling in Cancer Cells Proliferation by the Novel Antagonist TP455

Stefania Gessi, Serena Bencivenni, Enrica Battistello, +7

Frontiers in Pharmacology

The Identification of the 2-Phenylphthalazin-1(2<i>H</i>)-one Scaffold as a New Decorable Core Skeleton for the Design of Potent and Selective Human A₃Adenosine Receptor Antagonists

Daniela Poli, Daniela Catarzi, Vittoria Colotta, +7

Journal of Medicinal Chemistry

1,2,4-Triazolo[4,3-<i>a</i>]quinoxalin-1-one:  A Versatile Tool for the Synthesis of Potent and Selective Adenosine Receptor Antagonists

Vittoria Colotta, Daniela Catarzi, Flavia Varano, +5

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistrySelective AntagonistHeterocyclicAdenosine Receptors +12

New 2-Arylpyrazolo[3,4-<i>c</i>]quinoline Derivatives as Potent and Selective Human A₃Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand−Receptor Modeling Studies

Vittoria Colotta, Daniela Catarzi, Flavia Varano, +11

Journal of Medicinal Chemistry

4-Amido-2-aryl-1,2,4-triazolo[4,3-<i>a</i>]quinoxalin-1-ones as New Potent and Selective Human A₃Adenosine Receptor Antagonists. Synthesis, Pharmacological Evaluation, and Ligand−Receptor Modeling Studies

Ombretta Lenzi, Vittoria Colotta, Daniela Catarzi, +9

Journal of Medicinal Chemistry

Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-<i>d</i>]pyrimidine-5,7-diamine Derivatives: New Highly Potent A_2AAdenosine Receptor Inverse Agonists with Antinociceptive Activity

Flavia Varano, Daniela Catarzi, Fabrizio Vincenzi, +6

Journal of Medicinal Chemistry