Martine Clozel

Pharmacological characterization of bosentan, a new potent orally active nonpeptide endothelin receptor antagonist.

Martine Clozel, Volker Breu, Gillian A. Gray et al. · Journal of Pharmacology and Experimental Therapeutics · 1994 · 667 citations

Promotion of sleep by targeting the orexin system in rats, dogs and humans

Catherine Brisbare‐Roch, Jasper Dingemanse, Ralf Koberstein et al. · Nature Medicine · 2007 · 564 citations

Animal Physiology, Sleep Disorders, Sleep +15

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Martine Clozel, Volker Breu, Kaspar F. Burri et al. · Nature · 1993 · 529 citations

Medicine, Vascular Pharmacology, Physiology +5

The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo

Martine Clozel, Gillian A. Gray, Volker Breu et al. · Biochemical and Biophysical Research Communications · 1992 · 402 citations

Molecular Physiology, Medicine, Vascular Pharmacology +6

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

Marc Iglarz, Christoph A. Binkert, Keith Morrison et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 320 citations