Concepedia

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

Marc Iglarz, Christoph A. Binkert, Keith Morrison, Walter Fischli, John Gatfield, Alexander Treiber, Thomas Weller, Martin H. Bolli, Christoph Boss, Stephan Buchmann,

Journal of Pharmacology and Experimental Therapeutics · 2008 · 325 citations · 38 references

DOI

Concepts

References

38

The Immune Modulator FTY720 Targets Sphingosine 1-Phosphate Receptors

Volker Brinkmann, Michael D. Davis, Christopher E. Heise et al. · Journal of Biological Chemistry · 2002 · 1.5K citations · Full text

, , +17

Polar secretion of endothelin-1 by cultured endothelial cells.

Oswald Wagner, G Christ, Johann Wojta et al. · Journal of Biological Chemistry · 1992 · 643 citations · Full text

, , +9

Endothelin-A Receptor Antagonist–Mediated Vasodilatation Is Attenuated by Inhibition of Nitric Oxide Synthesis and by Endothelin-B Receptor Blockade

Marianne C. Verhaar, Fiona E. Strachan, David E. Newby et al. · Circulation · 1998 · 451 citations · Full text

, , +14

Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension.

Berthold Hocher, Christa Thöne‐Reineke, Peter Rohmeiss et al. · Journal of Clinical Investigation · 1997 · 410 citations · Full text

, , +17

Role of Endogenous Endothelin in Chronic Heart Failure

Paul Mulder, Vincent Richard, Geneviève Dérumeaux et al. · Circulation · 1997 · 361 citations

, , +17