Thomas Weller

Promotion of sleep by targeting the orexin system in rats, dogs and humans

Catherine Brisbare‐Roch, Jasper Dingemanse, Ralf Koberstein et al. · Nature Medicine · 2007 · 564 citations

Animal Physiology, Sleep Disorders, Sleep +15

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

Marc Iglarz, Christoph A. Binkert, Keith Morrison et al. · Journal of Pharmacology and Experimental Therapeutics · 2008 · 320 citations

Low molecular weight, non-peptide fibrinogen receptor antagonists

Leo Alig, Albrecht Edenhofer, Paul Hadváry et al. · Journal of Medicinal Chemistry · 1992 · 192 citations

2-Imino-thiazolidin-4-one Derivatives as Potent, Orally Active S1P₁Receptor Agonists

Martin H. Bolli, Stefan Abele, Christoph A. Binkert et al. · Journal of Medicinal Chemistry · 2010 · 173 citations · Full text

Molecular Pharmacology, 2-Imino-thiazolidin-4-one Derivatives, G Protein-coupled Receptor +13

The Discovery of <i>N</i>-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-<i>N</i>′-propylsulfamide (Macitentan), an Orally Active, Potent Dual Endothelin Receptor Antagonist

Martin H. Bolli, Christoph Boss, Christoph A. Binkert et al. · Journal of Medicinal Chemistry · 2012 · 146 citations · Full text

Hypertension, High Oral Efficacy, Compound 17 +18