De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

Longxing Cao, Inna Goreshnik, Brian Coventry, +12

Science

Design of protein-binding proteins from the target structure alone

Longxing Cao, Brian Coventry, Inna Goreshnik, +32

Nature

De novo design of luciferases using deep learning

Hsien‐Wei Yeh, Christoffer Norn, Yakov Kipnis, +15

Nature

De novo design of modular and tunable protein biosensors

Alfredo Quijano‐Rubio, Hsien‐Wei Yeh, Jooyoung Park, +12

Nature

Biomolecular ToolNatural SciencesMolecular BiologyTunable Protein BiosensorsProtein Engineering +2

Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice

Andrew C. Hunt, James Brett Case, Young‐Jun Park, +44

Science Translational Medicine

New VariantsViral DiagnosticsViral PathogenesisImmunologyMolecular Biology +15

Top-down design of protein architectures with reinforcement learning

Isaac D. Lutz, Shunzhi Wang, Christoffer Norn, +17

Science

Protein FoldingNatural SciencesMonte CarloMolecular BiologyStructural Biology +10

De novo design of picomolar SARS-CoV-2 miniprotein inhibitors

Longxing Cao, Inna Goreshnik, Brian Coventry, +11

Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease

James Brett Case, Rita E. Chen, Longxing Cao, +15

Cell Host & Microbe

pH-dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205

Longxing Cao, Xiangyi Shi, Haishuang Chang, +2

Proceedings of the National Academy of Sciences

ApoptosisImmunologyNecrotic CellsCell DeathMolecular Biology +20

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

Natasha I. Edman, Ashish Phal, Rachel L. Redler, +37

Cell

Tissue EngineeringFgf PathwayDevelopmental BiologyAngiogenesisEngineering +13