Concepedia

Receptor Selectivity Profiling

Receptor Selectivity Profiling is a systematic experimental and computational methodology that identifies and quantifies the binding interactions of a compound across a comprehensive panel of molecular targets to determine its specificity for intended receptors relative to off-targets within the broader landscape of pharmacologically relevant proteins.

475

Publications

23.1K

Citations

3.4K

Authors

564

Institutions

Publications per year

2017–2026

57

Parents

Publications

475

Receptor binding profile of R 41 468, A novel antagonist at 5-HT2 receptors

J.E. Leysen, F. Awouters, Ludo Kennis et al. · Life Sciences · 1981 · 846 citations

, , +13

Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide.

Sachie Suga, Kazuwa Nakao, Kiminori Hosoda et al. · Endocrinology · 1992 · 718 citations

, , +15

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

Terry Kenakin, Christian Watson, Vanessa Muniz‐Medina et al. · ACS Chemical Neuroscience · 2011 · 486 citations

, , +17

Uniform assessment and ranking of opioid Mu receptor binding constants for selected opioid drugs

Donna A. Volpe, R. Daniel Mellon, Aspandiar G. Katki et al. · Regulatory Toxicology and Pharmacology · 2011 · 440 citations

, , +14

Quantifying Ligand Bias at Seven-Transmembrane Receptors

Sudarshan Rajagopal, Seungkirl Ahn, David H. Rominger et al. · Molecular Pharmacology · 2011 · 390 citations

, , +17

1–5 of 475

Authors

3.4K

  1. BL
    Bryan L. Roth

    University of North Carolina at Chapel Hill, United States

    7 publications · 234 citations

    7

    h-index

  2. JÉ
    Judit Érchegyi

    University of Bern, Switzerland

    5 publications · 147 citations

    5

    h-index

  3. JC
    Jean Claude Reubi

    University of Bern, Switzerland

    5 publications · 147 citations

    5

    h-index

  4. FB
    Francesco Berardi

    University of Bari Aldo Moro, Italy

    5 publications · 149 citations

    5

    h-index

  5. JR
    Jean Rivier

    Salk Institute for Biological Studies, United States

    5 publications · 147 citations

    5

    h-index

1–5 of 3.4K

Institutions

564

  1. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    12 h-index

    124 publications

    3.9K citations

  2. Inserm

    Paris, France

    12 h-index

    74 publications

    3.2K citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    11 h-index

    51 publications

    2.3K citations

  4. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    11 h-index

    33 publications

    1.7K citations

  5. National Institutes of Health

    Bethesda, United States

    9 h-index

    53 publications

    2.4K citations

  6. Monash University

    Melbourne, Australia

    8 h-index

    28 publications

    1.5K citations

  7. Pfizer (United States)

    New York, United States

    8 h-index

    89 publications

    3.2K citations

  8. Uppsala University

    Uppsala, Sweden

    8 h-index

    44 publications

    2.4K citations

1–8 of 564

Venues

  1. Journal of Medicinal Chemistry

    117 publications · 5.2K citations

    46

    h-index

  2. 19

    h-index

  3. British Journal of Pharmacology

    BJP · 20 publications · 1.2K citations

    19

    h-index

  4. Bioorganic & Medicinal Chemistry Letters

    37 publications · 845 citations

    19

    h-index

  5. Bioorganic & Medicinal Chemistry

    17 publications · 336 citations

    12

    h-index

1–5