Concepedia

Off-target Liability Reduction

Off-Target Liability Reduction is a lead optimization strategy within medicinal chemistry aimed at minimizing unintended interactions of a drug candidate with non-primary biological targets, thereby enhancing its safety and selectivity profile.

12

Publications

271

Citations

114

Authors

21

Institutions

Publications per year

2017–2026

2

Parents

Children

Publications

12

Minimizing DILI risk in drug discovery — A screening tool for drug candidates

Simone Schadt, Silke Simon, Stefan Kustermann et al. · Toxicology in Vitro · 2015 · 88 citations

, , +12

A novel, covalent broad-spectrum inhibitor targeting human coronavirus Mpro

Jing Sun, Deheng Sun, Qi Yang et al. · Nature Communications · 2025 · 27 citations · Full text

, , +15

Off Target: Selection, Precaution, and Proportionality in the DoD 'Manual'

Adil Ahmad Haque · International law studies · 2016 · 24 citations

, , +13

The Importance of Being Profiled: Improving Drug Candidate Safety and Efficacy Using Ion Channel Profiling

Gregory J. Kaczorowski, María L. García, Jacob Bode et al. · Frontiers in Pharmacology · 2011 · 23 citations · Full text

, , +17

Avoiding hERG-liability in drug design via synergetic combinations of different (Q)SAR methodologies and data sources: a case study in an industrial setting

Thierry Hanser, Fabian P. Steinmetz, Jeffrey Plante et al. · Journal of Cheminformatics · 2019 · 21 citations · Full text

, , +14

1–5 of 12

Authors

114

  1. CM
    C. McGinnis

    Roche (Switzerland), Switzerland

    1 publications · 88 citations

    1

    h-index

  2. AA
    Adil Ahmad Haque

    Rutgers Sexual and Reproductive Health and Rights, Netherlands

    1 publications · 24 citations

    1

    h-index

  3. RA
    Robert A. Bohrer

    California Western School of Law, United States

    1 publications · 10 citations

    1

    h-index

  4. VS
    Volkmar Starke

    Roche (Switzerland), Switzerland

    1 publications · 88 citations

    1

    h-index

  5. SD
    Solomon D. Kattar

    Merck & Co., Inc., Rahway, NJ, USA (United States), United States

    1 publications · 14 citations

    1

    h-index

1–5 of 114

Institutions

21

  1. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    2 h-index

    34 publications

    472 citations

  2. University of Basel

    Basel, Switzerland

    1 h-index

    2 publications

    32 citations

  3. Charles University

    Prague, Czechia

    1 h-index

    2 publications

    32 citations

  4. United States Military Academy

    West Point, United States

    1 h-index

    1 publications

    14 citations

  5. Roche (Switzerland)

    Basel, Switzerland

    1 h-index

    24 publications

    2.1K citations

  6. Kaneka (United States)

    Pasadena, United States

    1 h-index

    1 publications

    23 citations

  7. Merck KGaA, Darmstadt (Germany)

    Darmstadt, Germany

    1 h-index

    3 publications

    63 citations

  8. Rutgers Sexual and Reproductive Health and Rights

    Utrecht, Netherlands

    1 h-index

    1 publications

    24 citations

1–8 of 21

Venues

  1. Journal of Chemical Information and Modeling

    JCIM · 1 publications · 13 citations

    1

    h-index

  2. 1

    h-index

  3. Planta Medica

    1 publications · 16 citations

    1

    h-index

  4. International law studies

    1 publications · 24 citations

    1

    h-index

  5. Inflammation Research

    IR · 1 publications · 15 citations

    1

    h-index

1–5