Minimizing DILI risk in drug discovery — A screening tool for drug candidates

Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

Lisa D. Marroquin, James T. Hynes, James A. Dykens et al. · Toxicological Sciences · 2007 · 630 citations

The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions

Karin Fattinger · Clinical Pharmacology & Therapeutics · 2001 · 501 citations · Full text

FDA-approved drug labeling for the study of drug-induced liver injury

Minjun Chen, Vikrant Vijay, Qiang Shi et al. · Drug Discovery Today · 2011 · 392 citations

Drug Safety, Hepatology, Medicine +10

High lipophilicity and high daily dose of oral medications are associated with significant risk for drug-induced liver injury

Minjun Chen, Jürgen Borlak, Weida Tong · Hepatology · 2012 · 357 citations

In Vitro Inhibition of the Bile Salt Export Pump Correlates with Risk of Cholestatic Drug-Induced Liver Injury in Humans

Sarah Dawson, Simone H. Stahl, Nikki R. Paul et al. · Drug Metabolism and Disposition · 2011 · 313 citations · Full text