Concepedia

Fragment-based Selectivity Design

Fragment-Based Selectivity Design is a fragment-based drug design strategy that specifically optimizes molecular fragments for selective target engagement by minimizing interactions with off-target proteins, thereby enhancing therapeutic precision.

18

Publications

681

Citations

157

Authors

41

Institutions

Publications per year

2017–2026

8

Parents

Publications

18

Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein

Andrew M. Petros, Steven L. Swann, Danying Song et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 80 citations · Full text

, , +16

Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics

Min Xu, Andrea Unzue, Jing Dong et al. · Journal of Medicinal Chemistry · 2015 · 75 citations · Full text

, , +17

A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066

Claudia De Fusco, P. Brear, Jessica Iegre et al. · Bioorganic & Medicinal Chemistry · 2017 · 68 citations · Full text

, , +15

Selectivity of Kinase Inhibitor Fragments

Paul Bamborough, Murray J. B. Brown, J.A. Christopher et al. · Journal of Medicinal Chemistry · 2011 · 66 citations · Full text

, , +17

Fragment-Based Design of Selective Nanomolar Ligands of the CREBBP Bromodomain

Andrea Unzue, Min Xu, Jing Dong et al. · Journal of Medicinal Chemistry · 2015 · 62 citations · Full text

, , +17

1–5 of 18

Authors

157

  1. AU
    Andrea Unzue

    University of Zurich, Switzerland

    2 publications · 137 citations

    2

    h-index

  2. JD
    Jing Dong

    Chinese Academy of Fishery Sciences, China

    2 publications · 137 citations

    2

    h-index

  3. MX
    Min Xu

    Dalian Medical University, China

    2 publications · 137 citations

    2

    h-index

  4. CN
    Cristina Nevado

    University of Zurich, Switzerland

    2 publications · 137 citations

    2

    h-index

  5. AC
    Amedeo Caflisch

    University of Zurich, Switzerland

    2 publications · 137 citations

    2

    h-index

1–5 of 157

Institutions

41

  1. University of Zurich

    Zurich, Switzerland

    2 h-index

    13 publications

    884 citations

  2. Xavier University of Louisiana

    New Orleans, United States

    1 h-index

    2 publications

    60 citations

  3. Centre National de la Recherche Scientifique

    Paris, France

    1 h-index

    1 publications

    26 citations

  4. Universidade Federal do ABC

    Santo André, Brazil

    1 h-index

    1 publications

    11 citations

  5. University of Cambridge

    Cambridge, United Kingdom

    1 h-index

    7 publications

    476 citations

  6. University of Bath

    Bath, United Kingdom

    1 h-index

    2 publications

    96 citations

  7. Wellcome Centre for Infectious Diseases Research in Africa

    Cape Town, South Africa

    1 h-index

    3 publications

    144 citations

  8. Tolero Pharmaceuticals (United States)

    Lehi, United States

    1 h-index

    4 publications

    64 citations

1–8 of 41

Venues

  1. Journal of Medicinal Chemistry

    6 publications · 295 citations

    6

    h-index

  2. Bioorganic & Medicinal Chemistry

    2 publications · 80 citations

    2

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    2 publications · 96 citations

    2

    h-index

  4. European Journal of Medicinal Chemistry

    2 publications · 27 citations

    2

    h-index

  5. Chemical Communications

    ChemComm · 1 publications · 20 citations

    1

    h-index

1–5