Murray J. B. Brown

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

Matthew P. Coghlan, Ainsley A. Culbert, Darren A.E. Cross et al. · Chemistry & Biology · 2000 · 895 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Repositioning of a Domain in a Modular Polyketide Synthase to Promote Specific Chain Cleavage

Jesús Cortés, Kirsten E. H. Wiesmann, Gareth A. Roberts et al. · Science · 1995 · 251 citations

Pharmacy, Biochemistry, Molecular Biology +17

Biocatalysis: A Pharma Perspective

Joseph P. Adams, Murray J. B. Brown, Alba Díaz‐Rodríguez et al. · Advanced Synthesis & Catalysis · 2019 · 223 citations · Full text

Life Sciences, Biotechnology, Pharmaceutical Biotechnology +12

Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase

Markus Schöber, Chris MacDermaid, Anne A. Ollis et al. · Nature Catalysis · 2019 · 218 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

A designed photoenzyme for enantioselective [2+2] cycloadditions

Jonathan S. Trimble, Rebecca Crawshaw, Florence J. Hardy et al. · Nature · 2022 · 208 citations · Full text

Natural Sciences, Biochemistry, Chemistry +6