Matthew P. Coghlan

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

Matthew P. Coghlan, Ainsley A. Culbert, Darren A.E. Cross et al. · Chemistry & Biology · 2000 · 888 citations · Full text

Biochemistry, Natural Sciences, Glycobiology +7

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

Francis S. Willard, Jonathan D. Douros, M Gabe et al. · JCI Insight · 2020 · 439 citations · Full text

Pharmacotherapy, Experimental Pharmacology, Insulin Signaling +20

Robust anti‐obesity and metabolic effects of a dual <scp>GLP</scp> ‐1/glucagon receptor peptide agonist in rodents and non‐human primates

Susan Henderson, Anish Konkar, David C. Hornigold et al. · Diabetes Obesity and Metabolism · 2016 · 233 citations · Full text

Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

Pamela A. Lochhead, Matthew P. Coghlan, Simon Q.J. Rice et al. · Diabetes · 2001 · 215 citations · Full text

Metabolic Remodeling, Insulin Signaling, Metabolic Syndrome +19

GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice

Ricardo J. Samms, Michael E. Christe, Kyla Collins et al. · Journal of Clinical Investigation · 2021 · 204 citations · Full text