Pamela A. Lochhead

5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.

Pamela A. Lochhead, Ian P. Salt, Kay S. Walker et al. · Diabetes · 2000 · 391 citations · Full text

Molecular Biology, Insulin Signaling, Protein Synthesis +19

Activation-Loop Autophosphorylation Is Mediated by a Novel Transitional Intermediate Form of DYRKs

Pamela A. Lochhead, Gary Sibbet, Nick Morrice et al. · Cell · 2005 · 318 citations · Full text

Activation-loop Autophosphorylation Is, Signal Transduction, Molecular Physiology +8

A Chaperone-Dependent GSK3β Transitional Intermediate Mediates Activation-Loop Autophosphorylation

Pamela A. Lochhead, Ross Kinstrie, Gary Sibbet et al. · Molecular Cell · 2006 · 271 citations · Full text

Signal Transduction, Signaling Pathway, Natural Sciences +6

Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

Pamela A. Lochhead, Matthew P. Coghlan, Simon Q.J. Rice et al. · Diabetes · 2001 · 215 citations · Full text

Metabolic Remodeling, Insulin Signaling, Metabolic Syndrome +19

Activating ROCK1 somatic mutations in human cancer

Pamela A. Lochhead, Grant Wickman, Mokdad Mezna et al. · Oncogene · 2010 · 93 citations

Somatic Variant, Oncogenic Agent, Rock1 Somatic Mutations +5