2-Anilino-4-(thiazol-5-yl)pyrimidine CDK Inhibitors:  Synthesis, SAR Analysis, X-ray Crystallography, and Biological Activity

Shudong Wang, Christopher Meades, Gavin Wood, +16

Journal of Medicinal Chemistry

X-ray CrystallographyMolecular DockingMedicinal ChemistryVirtual ScreeningPyrimidine Cdk Inhibitors +13

Pharmacological properties of the Ca²⁺‐release mechanism sensitive to NAADP in the sea urchin egg

Armando A. Genazzani, Mokdad Mezna, Deborah M. Dickey, +2

British Journal of Pharmacology

Experimental PharmacologyCellular PhysiologyMolecular PharmacologyCyclic Adp RiboseNaadp Receptors +14

Discovery and Characterization of 2-Anilino-4- (Thiazol-5-yl)Pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents

Shudong Wang, Gary Griffiths, Carol Midgley, +19

Chemistry & Biology

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +5

Discovery of<i>N</i>-Phenyl-4-(thiazol-5-yl)pyrimidin-2-amine Aurora Kinase Inhibitors

Shudong Wang, Carol Midgley, Frédéric Scaërou, +18

Journal of Medicinal Chemistry

Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance

Campbell McInnes, A. Mazumdar, Mokdad Mezna, +9

Nature Chemical Biology

Protein FunctionSignal TransductionNatural SciencesReceptor Tyrosine KinaseMolecular Biology +6

Activating ROCK1 somatic mutations in human cancer

Pamela A. Lochhead, Grant Wickman, Mokdad Mezna, +1

Oncogene

Somatic VariantOncogenic AgentRock1 Somatic MutationsCancer GeneticsMedicine +3

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

Jennifer Port, Nathiya Muthalagu, Meera Raja, +22

Cancer Discovery

Differential Binding of Inhibitors to Active and Inactive CDK2 Provides Insights for Drug Design

George Kontopidis, Campbell McInnes, S. Pandalaneni, +8

Chemistry & Biology

Molecular DockingDrug TargetSignal TransductionDrug DesignMedicine +8

A novel small-molecule MRCK inhibitor blocks cancer cell invasion

Mathieu Unbekandt, Daniel R. Croft, Diane Crighton, +10

Cell Communication and Signaling

Structural Determinants of CDK4 Inhibition and Design of Selective ATP Competitive Inhibitors

Campbell McInnes, Shudong Wang, Sian Anderson, +9

Chemistry & Biology

Signal TransductionBiochemistryMolecular PathwayStructural DeterminantsNatural Sciences +9