Shudong Wang

<i>In vitro</i> and <i>in vivo</i> antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R‐roscovitine)

Steven J. McClue, David Blake, Rosemary G. Clarke et al. · International Journal of Cancer · 2002 · 363 citations · Full text

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK Inhibitors:  Synthesis, SAR Analysis, X-ray Crystallography, and Biological Activity

Shudong Wang, Christopher Meades, Gavin Wood et al. · Journal of Medicinal Chemistry · 2004 · 151 citations · Full text

X-ray Crystallography, Molecular Docking, Medicinal Chemistry +15

Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

Hao Shao, Shenhua Shi, Shi‐Liang Huang et al. · Journal of Medicinal Chemistry · 2013 · 121 citations · Full text

Structure–activity Relationship, Drug Target, Heterocycle Chemistry +17

Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors

Zhijian Xu, Zheng Liu, Tong Chen et al. · Journal of Medicinal Chemistry · 2011 · 120 citations

Halogenation, Halogen Bond, Medicinal Chemistry +14

Discovery of a Novel Family of CDK Inhibitors with the Program LIDAEUS

S. Y. Wu, I.W. McNae, George Kontopidis et al. · Structure · 2003 · 105 citations · Full text

Cdk Inhibitors, Medicinal Chemistry, Medicine +12