Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

Francis S. Willard, Jonathan D. Douros, M Gabe, +15

JCI Insight

PharmacotherapyExperimental PharmacologyInsulin SignalingObesityMolecular Pharmacology +18

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

Kristin A. Anderson, Frank K. Huynh, Kelsey H. Fisher‐Wellman, +17

Cell Metabolism

BiochemistryControls Leucine MetabolismDiabetesLysine DeacylaseMetabolic Regulation +6

Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice

Patrick J. Knerr, Stephanie A. Mowery, Jonathan D. Douros, +8

Molecular Metabolism

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

Kimberley El, Jonathan D. Douros, Francis S. Willard, +14

Nature Metabolism

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice

Arkadiusz Liśkiewicz, Ahmed Khalil, Daniela Liśkiewicz, +28

Nature Metabolism

GLP-1-directed NMDA receptor antagonism for obesity treatment

Jonas Petersen, Mette Q. Ludwig, Vaida Juozaityte, +30

Nature

The Limited Role of Glucagon for Ketogenesis During Fasting or in Response to SGLT2 Inhibition

Megan E. Capozzi, Reilly W. Coch, Jepchumba Koech, +10

Diabetes

Renal InflammationCellular PhysiologyInsulin SignalingMolecular PharmacologyMetabolic Syndrome +23

Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

Bin Yang, Vasily M. Gelfanov, Kimberley El, +10

Molecular Metabolism

Control of leptin by metabolic state and its regulatory interactions with pituitary growth hormone and hepatic growth hormone receptors and insulin like growth factors in the tilapia ( Oreochromis mossambicus )

Jonathan D. Douros, David A. Baltzegar, Jamie L. Mankiewicz, +7

General and Comparative Endocrinology

Animal PhysiologyBiologyGrowth HormoneEndocrine MechanismHuman Growth +12

Leptin Stimulates Cellular Glycolysis Through a STAT3 Dependent Mechanism in Tilapia

Jonathan D. Douros, David A. Baltzegar, Benjamin J. Reading, +4

Frontiers in Endocrinology