LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

Tamer Coşkun, Kyle W. Sloop, Corina Loghin, +13

Molecular Metabolism

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

Simon C. Cork, James E. Richards, Marie K. Holt, +3

Molecular Metabolism

Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock

Kenneth A. Dyar, Stefano Ciciliot, Lauren E. Wright, +17

Molecular Metabolism

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

Thaís de Castro Barbosa, Lars R. Ingerslev, Petter S. Alm, +11

Molecular Metabolism

Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets

Michael R. DiGruccio, Alex M. Mawla, Cynthia J. Donaldson, +5

Molecular Metabolism

Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes

Amanda M. Ackermann, Zhiping Wang, Jonathan Schug, +2

Molecular Metabolism

Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells

Maja S. Engelstoft, Won-Mee Park, Ichiro Sakata, +17

Molecular Metabolism

Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals

Christian Benedict, Heike Vogel, Wenke Jonas, +4

Molecular Metabolism

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

Tinh‐Hai Collet, B. Dubern, Jacek Mokrosiński, +25

Molecular Metabolism

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

Phillip J. White, Amanda L. Lapworth, Jie An, +11

Molecular Metabolism