Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

Brian Finan, Tao Ma, Nickki Ottaway, +30

Science Translational Medicine

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

Brian Finan, Bin Yang, Nickki Ottaway, +26

Nature Medicine

ObesityMetabolic SyndromeNeuropeptidesBiochemistryMedicine +9

LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor

Xuecai Ge, Hong Yang, Maria A. Bednarek, +13

Cell Metabolism

Molecular PhysiologySignal TransductionG Protein-coupled ReceptorMedicinePhysiology +5

Cellular origins of cold‐induced brown adipocytes in adult mice

Yun‐Hee Lee, Anelia Petkova, Anish Konkar, +1

The FASEB Journal

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

Kirk M. Habegger, Kerstin Stemmer, Christine C. Cheng, +24

Diabetes

Cell GrowthCellular PhysiologyInsulin SignalingGastrointestinal Peptide HormoneObesity +22

Robust anti‐obesity and metabolic effects of a dual <scp>GLP</scp> ‐1/glucagon receptor peptide agonist in rodents and non‐human primates

Susan Henderson, Anish Konkar, David C. Hornigold, +19

Diabetes Obesity and Metabolism

Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist

Martin Bossart, Michael Wagner, Ralf Elvert, +23

Cell Metabolism

A novel glucagon‐like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice

M. Pilar Valdecantos, Virginia Pardo, Laura Ruíz-Cañas, +18

Hepatology

beta1-adrenergic receptors mediate beta3-adrenergic-independent effects of CGP 12177 in brown adipose tissue.

Anish Konkar, Ying Zhai, James G. Granneman

PubMed

ImmunologyBrown FatCgp 20712Cellular PhysiologyGastrointestinal Peptide Hormone +22

Aryloxypropanolamine and catecholamine ligand interactions with the beta(1)-adrenergic receptor: evidence for interaction with distinct conformations of beta(1)-adrenergic receptors.

Anish Konkar, Zhengxian Zhu, James G. Granneman

PubMed

PharmacotherapyCatecholamine Ligand InteractionsMolecular PharmacologyMedicinal ChemistryAdrenal Gland +17