Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

Brian Finan, Tao Ma, Nickki Ottaway, +30

Science Translational Medicine

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

Brian Finan, Bin Yang, Nickki Ottaway, +26

Nature Medicine

ObesityMetabolic SyndromeNeuropeptidesBiochemistryMedicine +9

Targeted estrogen delivery reverses the metabolic syndrome

Brian Finan, Bin Yang, Nickki Ottaway, +23

Nature Medicine

ObesityMetabolic SyndromeEndocrine MechanismEstrogen DeliveryMedicine +5

Optimized GIP analogs promote body weight lowering in mice through GIPR agonism not antagonism

Piotr Mróz, Brian Finan, Vasily M. Gelfanov, +4

Molecular Metabolism

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

Brian Finan, Christoffer Clemmensen, Zhimeng Zhu, +39

Cell

Metabolic SyndromeBiochemistryMedicineMetabolic DiseaseMetabolic Regulation +8

Targeted pharmacological therapy restores β-cell function for diabetes remission

Stephan Sachs, Aimée Bastidas-Ponce, Sophie Tritschler, +24

Nature Metabolism

Diabetes ManagementMedicineDiabetes RemissionDiabetesDiabetes Mellitus +2

Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice

Xuehong Cao, Pingwen Xu, Mario G. Oyola, +18

Journal of Clinical Investigation

NeuroendocrinologyFemale Reproductive FunctionSocial SciencesReproductive EndocrinologyMolecular Pharmacology +19

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

Kimberley El, Jonathan D. Douros, Francis S. Willard, +14

Nature Metabolism

Estrogen receptor–α in medial amygdala neurons regulates body weight

Pingwen Xu, Xuehong Cao, Yanlin He, +21

Journal of Clinical Investigation

Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity

Carmelo Quarta, Christoffer Clemmensen, Zhimeng Zhu, +33

Cell Metabolism

ObesityMetabolic SyndromeEnergy HomeostasisBody CompositionAutoimmune Disease +12