Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans

Brian Finan, Tao Ma, Nickki Ottaway, +30

Science Translational Medicine

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

Jonathan W. Day, Nickki Ottaway, James T Patterson, +22

Nature Chemical Biology

ObesityMetabolic SyndromeEnergy HomeostasisGastrointestinal Peptide HormoneMedicine +10

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

Brian Finan, Bin Yang, Nickki Ottaway, +26

Nature Medicine

ObesityMetabolic SyndromeNeuropeptidesBiochemistryMedicine +9

Targeted estrogen delivery reverses the metabolic syndrome

Brian Finan, Bin Yang, Nickki Ottaway, +23

Nature Medicine

ObesityMetabolic SyndromeEndocrine MechanismEstrogen DeliveryMedicine +5

Hormones and diet, but not body weight, control hypothalamic microglial activity

Yuanqing Gao, Nickki Ottaway, Sonja C. Schriever, +13

Glia

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

Kirk M. Habegger, Kerstin Stemmer, Christine C. Cheng, +24

Diabetes

Cell GrowthCellular PhysiologyInsulin SignalingGastrointestinal Peptide HormoneObesity +22

Restoration of leptin responsiveness in diet‐induced obese mice using an optimized leptin analog in combination with exendin‐4 or FGF21

Timo D. Müller, Lorraine M. Sullivan, Kirk M. Habegger, +16

Journal of Peptide Science

Diet-Induced Obese Mice Retain Endogenous Leptin Action

Nickki Ottaway, Parinaz Mahbod, Belén Rivero‐Gutiérrez, +3

Cell Metabolism

ObesityMetabolic SyndromeBody CompositionAppetite ControlPhysiology +6

p62 Links β-adrenergic input to mitochondrial function and thermogenesis

Timo D. Müller, Sang Jun Lee, Martin Jastroch, +32

Journal of Clinical Investigation

Cell DeathMitochondrial BiologyMetabolic RemodelingCellular PhysiologyOxidative Stress +19

Both Acyl and Des-Acyl Ghrelin Regulate Adiposity and Glucose Metabolism via Central Nervous System Ghrelin Receptors

Kristy M. Heppner, Carolin L. Piechowski, Anne Müller, +10

Diabetes

Intracerebroventricular DagInsulin SignalingGastrointestinal Peptide HormoneObesityMetabolic Syndrome +15