Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

Monika Wolf, Arlind Adili, Kira Piotrowitz, +24

Cancer Cell

InflammationHepatologyHepatocellular CarcinomaMetabolic ActivationLiver Physiology +9

Targeted estrogen delivery reverses the metabolic syndrome

Brian Finan, Bin Yang, Nickki Ottaway, +23

Nature Medicine

ObesityMetabolic SyndromeEndocrine MechanismEstrogen DeliveryMedicine +5

Plasma proteome profiling discovers novel proteins associated with non‐alcoholic fatty liver disease

Lili Niu, Philipp E. Geyer, Nicolai J. Wewer Albrechtsen, +14

Molecular Systems Biology

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

Qian Zhang, Tenagne D. Challa, Robert Augustin, +33

Cell Metabolism

Fibroblast Growth Factor 21 Mediates Specific Glucagon Actions

Kirk M. Habegger, Kerstin Stemmer, Christine C. Cheng, +24

Diabetes

Cell GrowthCellular PhysiologyInsulin SignalingGastrointestinal Peptide HormoneObesity +22

Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling

Daniel A. Giles, Maria E. Moreno‐Fernandez, Traci E. Stankiewicz, +24

Nature Medicine

ObesityMetabolic SyndromeHepatologyLiver PhysiologyPhysiology +8

The role of organic anion transporting polypeptides (OATPs/SLCOs) in the toxicity of different microcystin congeners in vitro: A comparison of primary human hepatocytes and OATP-transfected HEK293 cells

Andreas Fischer, Stefan J. Hoeger, Kerstin Stemmer, +4

Toxicology and Applied Pharmacology

AllergyOatp-transfected Hek293 CellsMedicineLiver PhysiologyOrganic Anion +9

Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease

Brian Finan, Christoffer Clemmensen, Zhimeng Zhu, +39

Cell

Metabolic SyndromeBiochemistryMedicineMetabolic DiseaseMetabolic Regulation +8

A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution

Adriano Maida, Annika Zota, Kim A. Sjøberg, +14

Journal of Clinical Investigation

NutritionMetabolic DisorderInsulin SignalingOxidative StressObesity +20

Diet-induced alteration of intestinal stem cell function underlies obesity and prediabetes in mice

Alexandra Aliluev, Sophie Tritschler, Michael Sterr, +15

Nature Metabolism