Biocatalysis: A Pharma Perspective

TLDR

Biocatalysis has become an essential, cost‑effective, sustainable tool in pharma manufacturing, with established reaction classes and rapidly developing new enzyme classes, though many promising enzymes still need investment. The paper outlines GSK’s perspective on the current status of biocatalysis in pharma manufacturing and highlights areas of significant potential. Figure: magnified image.

Abstract

Abstract Biocatalysis over the past few years has matured into an essential tool for modern, cost effective and sustainable pharmaceutical manufacturing. While some reaction classes are well established, and may even be the option of first intent, other more recently discovered enzyme classes are being rapidly developed both in academia and industry. Notwithstanding this, there are further promising enzymes that require further investment and investigation to allow their future industrial use. We here outline GSK's perspective on the current status of biocatalysis for pharmaceutical manufacturing and provide our views on areas of significant potential. magnified image