Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

Christopher K. Savile, Jacob M. Janey, Emily C. Mundorff, +10

Science

EngineeringBiocatalytic Asymmetric SynthesisOrganic ChemistryPharmaceutical SynthesisMedicinal Chemistry +15

Chiral Amine Synthesis – Recent Developments and Trends for Enamide Reduction, Reductive Amination, and Imine Reduction

Thomas C. Nugent, Mohamed El‐Shazly

Advanced Synthesis & Catalysis

Enamide ReductionEngineeringChiral Amine LiteratureNatural SciencesDiversity-oriented Synthesis +11

Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades

Francesco G. Mutti, Tanja Knaus, Nigel S. Scrutton, +2

Science

EngineeringBiochemistryNatural SciencesBiocatalysisDiversity-oriented Synthesis +13

Engineering an Enantioselective Amine Oxidase for the Synthesis of Pharmaceutical Building Blocks and Alkaloid Natural Products

Diego Ghislieri, Anthony P. Green, Marta Pontini, +5

Journal of the American Chemical Society

Combinatorial ChemistryEngineeringOrganic ChemistryMonoamine Oxidase VariantsMedicinal Chemistry +16

A platform for the discovery of new macrolide antibiotics

Ian B. Seiple, Ziyang Zhang, Pavol Jakubec, +13

Nature

Antimicrobial Drug DiscoveryAntibioticsMedicineAntibacterial AgentAntimicrobial Chemotherapy +6

Metal−Brønsted Acid Cooperative Catalysis for Asymmetric Reductive Amination

Chaoqun Li, Barbara Villa‐Marcos, Jianliang Xiao

Journal of the American Chemical Society

Palladium-catalysed transannular C–H functionalization of alicyclic amines

Joseph J. Topczewski, Pablo J. Cabrera, Noam I. Saper, +1

Nature

EngineeringAlicyclic AminesOrganic ChemistryOrganometallic CatalysisCatalysis +1

ω-Transaminases for the Production of Optically Pure Amines and Unnatural Amino Acids

Sam Mathew, Hyungdon Yun

ACS Catalysis

Pure Amine CompoundsBiosynthesisMaterials SynthesisEngineeringBiochemistry +13

Development of an Amine Dehydrogenase for Synthesis of Chiral Amines

Michael J. Abrahamson, Eduardo Vázquez‐Figueroa, Nicholas B. Woodall, +2

Angewandte Chemie International Edition

Asymmetric CatalysisMethyl GroupBiosynthesisEngineeringBiochemistry +12

Recent Developments of Cascade Reactions Involving ω-Transaminases

Robert C. Simon, Nina Richter, Wolfgang Kroutil

ACS Catalysis

Asymmetric CatalysisBiosynthesisEngineeringEnzymatic Cascade ReactionsBiochemistry +10