Gheorghe‐Doru Roiban

Biocatalysis: A Pharma Perspective

Joseph P. Adams, Murray J. B. Brown, Alba Díaz‐Rodríguez et al. · Advanced Synthesis & Catalysis · 2019 · 220 citations · Full text

Biosynthesis, Abstract Biocatalysis, Enzyme Classes +15

Chiral synthesis of LSD1 inhibitor GSK2879552 enabled by directed evolution of an imine reductase

Markus Schöber, Chris MacDermaid, Anne A. Ollis et al. · Nature Catalysis · 2019 · 209 citations

Pharmaceutical Chemistry, Biochemistry, Natural Sciences +8

Expanding the toolbox of organic chemists: directed evolution of P450 monooxygenases as catalysts in regio- and stereoselective oxidative hydroxylation

Gheorghe‐Doru Roiban, Manfred T. Reetz · Chemical Communications · 2014 · 151 citations

Achieving Regio‐ and Enantioselectivity of P450‐Catalyzed Oxidative CH Activation of Small Functionalized Molecules by Structure‐Guided Directed Evolution

Rubén Agudo, Gheorghe‐Doru Roiban, Manfred T. Reetz · ChemBioChem · 2012 · 115 citations

Efficient Biocatalytic Reductive Aminations by Extending the Imine Reductase Toolbox

Gheorghe‐Doru Roiban, Marcelo Kern, Zhi Liu et al. · ChemCatChem · 2017 · 94 citations

Engineering, Aldo-keto Reductase, Enzymatic Modification +17