Concepedia

Allosteric Selectivity Design

Allosteric Selectivity Design is a methodological framework within off-target liability reduction that exploits allosteric binding sites to confer target specificity by modulating protein conformational dynamics in a manner distinct from orthosteric ligand interactions.

3

Publications

94

Citations

33

Authors

6

Institutions

Publications per year

2017–2026

1

Parents

Publications

3

Design and optimization of selective azaindole amide M1 positive allosteric modulators

Jennifer E. Davoren, Steven V. O’Neil, Dennis P. Anderson et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 44 citations · Full text

, , +13

Selectivity hot-spots of sirtuin catalytic cores

Marco Parenti, Santina Bruzzone, Alessio Nencioni et al. · Molecular BioSystems · 2015 · 29 citations

, , +16

Design, synthesis, activity and molecular dynamics studies of 1,3,4-thiadiazole derivatives as selective allosteric inhibitors of SHP2 for the treatment of cancer

Wen-Shan Liu, Jifeng Zhao, Xiaojing Guo et al. · European Journal of Medicinal Chemistry · 2023 · 21 citations · Full text

, , +16

1–3 of 3

Authors

33

  1. SV
    Steven V. O’Neil

    Pfizer (United States), United States

    1 publications · 44 citations

    1

    h-index

  2. MG
    Michael Green

    National Institute of Health Sciences, Japan

    1 publications · 44 citations

    1

    h-index

  3. RS
    Romelia Salomón–Ferrer

    Lawrence Berkeley National Laboratory, United States

    1 publications · 44 citations

    1

    h-index

  4. RS
    R. Scott Obach

    Pfizer (United States), United States

    1 publications · 44 citations

    1

    h-index

  5. SG
    Sarah Grimwood

    Pfizer (United States), United States

    1 publications · 44 citations

    1

    h-index

1–5 of 33

Institutions

6

  1. Weifang Medical University

    Weifang, China

    1 h-index

    7 publications

    147 citations

  2. University of Genoa

    Genoa, Italy

    1 h-index

    2 publications

    58 citations

  3. University of Bologna

    Bologna, Italy

    1 h-index

    2 publications

    58 citations

  4. Pfizer (United States)

    New York, United States

    1 h-index

    23 publications

    1K citations

  5. National Academies of Sciences, Engineering, and Medicine

    Washington, United States

    1 h-index

    1 publications

    29 citations

  6. Institute of Organic Synthesis and Photoreactivity

    Bologna, Italy

    1 h-index

    1 publications

    29 citations

1–6 of 6

Venues

  1. European Journal of Medicinal Chemistry

    1 publications · 21 citations

    1

    h-index

  2. Molecular BioSystems

    1 publications · 29 citations

    1

    h-index

  3. Bioorganic & Medicinal Chemistry Letters

    1 publications · 44 citations

    1

    h-index

1–3