Steven V. O’Neil

Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression

Zoë A. Hughes, Sarah J. Neal Webb, Daniel L. Smith et al. · Neuropharmacology · 2012 · 85 citations

Psychiatry, Negative Allosteric Modulation, Treatment Resistant Depression +12

Discovery of the Potent and Selective M1 PAM-Agonist<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-Hydroxytetrahydro-2<i>H</i>-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

Jennifer E. Davoren, Che‐Wah Lee, Michelle R. Garnsey et al. · Journal of Medicinal Chemistry · 2016 · 83 citations · Full text

Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation

Laura A. McAllister, Christopher R. Butler, Scot Mente et al. · Journal of Medicinal Chemistry · 2018 · 78 citations · Full text

Chemical Biology, Medicinal Chemistry, Pharmaceutical Science +14

Design and Synthesis of γ- and δ-Lactam M₁ Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M₁-Selective PAM with Weak Agonist Activity

Jennifer E. Davoren, Michelle R. Garnsey, Betty Pettersen et al. · Journal of Medicinal Chemistry · 2017 · 58 citations · Full text

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis

Corey R. Hopkins, Steven V. O’Neil, Michael C. Laufersweiler et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 49 citations · Full text

Biochemistry, Medicine, Potential Application +7