Concepedia

Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis

Corey R. Hopkins, Steven V. O’Neil, Michael C. Laufersweiler, Yili Wang, Matthew Pokross, Marlene Mekel, A.G. Evdokimov, Richard Walter, Maria Kontoyianni, Maria E. Petrey,

Bioorganic & Medicinal Chemistry Letters · 2006 · 49 citations · 25 references

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Concepts

References

25

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

Robert T. Nolte, G. Bruce Wisely, Stefan Westin et al. · Nature · 1998 · 1.9K citations

, , +12

PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

Yaacov Barak, Michael C. Nelson, Estelita S. Ong et al. · Molecular Cell · 1999 · 1.9K citations · Full text

, , +12

PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

Toru Akune, Shinsuke Ohba, Satoru Kamekura et al. · Journal of Clinical Investigation · 2004 · 786 citations · Full text

, , +17

PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

Toru Akune, Shinsuke Ohba, Satoru Kamekura et al. · Journal of Clinical Investigation · 2004 · 728 citations · Full text

, , +17

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα

H. Eric Xu, Thomas B. Stanley, Valerie G. Montana et al. · Nature · 2002 · 611 citations

, , +16