R.L. Palte

Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors

Mitchell H. Keylor, Anmol Gulati, Solomon D. Kattar et al. · Journal of Medicinal Chemistry · 2021 · 40 citations · Full text

Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5)

R.L. Palte, Sebastian E. Schneider, Michael D. Altman et al. · ACS Medicinal Chemistry Letters · 2020 · 38 citations · Full text

The Discovery of Two Novel Classes of 5,5-Bicyclic Nucleoside-Derived PRMT5 Inhibitors for the Treatment of Cancer

Ryan V. Quiroz, Michael H. Reutershan, Sebastian E. Schneider et al. · Journal of Medicinal Chemistry · 2021 · 33 citations · Full text

Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy

Matthew J. Mitcheltree, Derun Li, Abdelghani Achab et al. · ACS Medicinal Chemistry Letters · 2020 · 30 citations · Full text

Discovery of <i>N</i>-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases

Hongjun Zhang, Blair T. Lapointe, Neville J. Anthony et al. · ACS Medicinal Chemistry Letters · 2020 · 24 citations · Full text