Abdelghani Achab - Concepedia

Author

Abdelghani Achab

Merck & Co., Inc., Rahway, NJ, USA (United States)

Also Known As

Abdelghani Achab

Publications

318

Citations

H-Index

Concepts

All Affiliations

Merck & Co., Inc., Rahway, NJ, USA (United States)Quantitative BioSciences WuXi AppTec (China)

About

Abdelghani Achab is an author at Merck & Co., Inc., Rahway, NJ, USA (United States) specializing in drug discovery, medicinal chemistry, and medicine.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Medicine	6	6	147
2	Natural Sciences	6	6	147
3	Biochemistry	5	5	129
4	Chemical Biology	5	5	136
5	Biomolecular Engineering	1	1	48

Abdelghani Achab

Publications

308

Citations

H-Index

Page 1

	Year	Citations
Structural characterization of nonactive site, TrkA-selective kinase inhibitors Hua-Poo Su, Keith Rickert, Christine Burlein, Proceedings of the National Academy of Sciences Nonactive SiteMedicinal ChemistryDrug TargetSignal TransductionTrka Selectivity	2016	48
Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds Brandon Vara, Samuel M. Levi, Abdelghani Achab, ACS Medicinal Chemistry Letters	2021	47
Discovery of Amino-cyclobutarene-derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors for Cancer Immunotherapy Hongjun Zhang, K. Liu, Qinglin Pu, ACS Medicinal Chemistry Letters	2019	44
Discovery and Hit-to-Lead Optimization of Non-ATP Competitive MK2 (MAPKAPK2) Inhibitors Xiaohua Huang, Gerald W. Shipps, Cliff C. Cheng, ACS Medicinal Chemistry Letters Drug TargetBioorganic ChemistryExcellent Kinase SelectivityChemical BiologyPharmaceutical Chemistry	2011	33
Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy Matthew J. Mitcheltree, Derun Li, Abdelghani Achab, ACS Medicinal Chemistry Letters	2020	30
Carbamate and <i>N</i>-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1 Inhibitors Derun Li, Yongqi Deng, Abdelghani Achab, ACS Medicinal Chemistry Letters	2021	25
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors Derun Li, Hongjun Zhang, Thomas W. Lyons, ACS Medicinal Chemistry Letters Combinatorial ChemistryPotent Arginase InhibitorsPeptide ScienceChemical BiologyPharmaceutical Chemistry	2021	19
Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow Xavier Fradera, Joey L. Methot, Abdelghani Achab, Bioorganic & Medicinal Chemistry Letters Medicinal ChemistrySelective Pi3kδ InhibitorsMedicineNatural SciencesPharmacology	2019	18
Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing Derun Li, David L. Sloman, Abdelghani Achab, Journal of Medicinal Chemistry Amide HydrolysisUnconventional AmideDrug TargetBioorganic ChemistryPharmacotherapy	2022	18
Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors Joey L. Methot, Abdelghani Achab, Matthew Christopher, ACS Medicinal Chemistry Letters	2020	15

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