MK-5172, a Selective Inhibitor of Hepatitis C Virus NS3/4a Protease with Broad Activity across Genotypes and Resistant Variants

Vincenzo Summa, Steven W. Ludmerer, John A. McCauley, +22

Antimicrobial Agents and Chemotherapy

Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor

Steven J. Harper, John A. McCauley, Michael T. Rudd, +32

ACS Medicinal Chemistry Letters

ImmunologyMolecular BiologyPharmacotherapyAntiviral DrugMedicinal Chemistry +17

Structure−Activity Relationship of Purine Ribonucleosides for Inhibition of Hepatitis C Virus RNA-Dependent RNA Polymerase

Anne B. Eldrup, Charles Allerson, C. Frank Bennett, +17

Journal of Medicinal Chemistry

Medicinal ChemistryViral ReplicationBiochemistryViral Polymerase StructureStructure−activity Relationship +13

Structure−Activity Relationship of Heterobase-Modified 2‘-<i>C</i>-Methyl Ribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

Anne B. Eldrup, Marija Prhavc, Jennifer L. Brooks, +24

Journal of Medicinal Chemistry

Design, Synthesis, and X-ray Crystallographic Analysis of a Novel Class of HIV-1 Protease Inhibitors

Ashit K. Ganguly, S. Alluri, D. Caroccia, +10

Journal of Medicinal Chemistry

Structural characterization of nonactive site, TrkA-selective kinase inhibitors

Hua-Poo Su, Keith Rickert, Christine Burlein, +27

Proceedings of the National Academy of Sciences

Nonactive SiteMedicinal ChemistryDrug TargetSignal TransductionTrka Selectivity +13

Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics

James C. Barrow, Philippe G. Nantermet, Shaun R. Stauffer, +16

Journal of Medicinal Chemistry

PharmacotherapyNovel AntithromboticsThrombosisMedicinal ChemistryHematology +15

Structural optimization of cyclic sulfonamide based novel HIV-1 protease inhibitors to picomolar affinities guided by X-ray crystallographic analysis

Ashit K. Ganguly, S. Alluri, Chih‐Hung Wang, +11

Tetrahedron

Medicinal ChemistryBiochemistryProtein AssemblyNatural SciencesMedicine +11

A time-resolved, internally quenched fluorescence assay to characterize inhibition of hepatitis C virus nonstructural protein 3–4A protease at low enzyme concentrations

Shi‐Shan Mao, Jillian DiMuzio, Carolyn McHale, +3

Analytical Biochemistry

Protein ChemistryVirus StructureBiochemistryFluorescence AssayViral Hepatitis +8

Electrochemiluminescence assay for basic carboxypeptidases: inhibition of basic carboxypeptidases and activation of thrombin-activatable fibrinolysis inhibitor

Shi‐Shan Mao, Dennis Colussi, Carolyn Bailey, +4

Analytical Biochemistry

Electrochemiluminescence AssayBiochemistryBasic CarboxypeptidasesMedicineBioanalysis +4