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Binding Site Divergence Analysis

Binding Site Divergence Analysis is a computational method used in off-target liability reduction that identifies and quantifies evolutionary or structural variations in binding sites across protein homologs to assess the potential for selective versus promiscuous drug targeting.

7

Publications

398

Citations

36

Authors

32

Institutions

Publications per year

2017–2026

3

Parents

Publications

7

Predicted structures of the cGMP binding domains of the cGMP-dependent protein kinase: a key alanine/threonine difference in evolutionary divergence of cAMP and cGMP binding sites

Irene T. Weber, John B. Shabb, Jackie D. Corbin · Biochemistry · 1989 · 125 citations

, , +14

Tracing the Evolutionary History of Drosophila Regulatory Regions with Models that Identify Transcription Factor Binding Sites

E. T. Dermitzakis · Molecular Biology and Evolution · 2003 · 88 citations · Full text

, , +17

Limited conservation in cross-species comparison of GLK transcription factor binding suggested wide-spread cistrome divergence

Xiaoyu Tu, Sibo Ren, Wei Shen et al. · Nature Communications · 2022 · 68 citations · Full text

, , +15

Convergent and lineage-specific genomic differences in limb regulatory elements in limbless reptile lineages

Juliana G. Roscito, Katrin Sameith, Bogdan Kirilenko et al. · Cell Reports · 2022 · 46 citations · Full text

, , +17

Duplicate Gene Divergence by Changes in MicroRNA Binding Sites in Arabidopsis and Brassica

Sishuo Wang, Keith L. Adams · Genome Biology and Evolution · 2015 · 26 citations · Full text

, , +17

1–5 of 7

Authors

36

  1. JG
    Juliana G. Roscito

    Max Planck Institute for the Physics of Complex Systems, Germany

    2 publications · 67 citations

    2

    h-index

  2. MH
    Michael Hiller

    Max Planck Institute of Molecular Cell Biology and Genetics, Germany

    2 publications · 67 citations

    2

    h-index

  3. BK
    Bogdan Kirilenko

    LOEWE Centre for Translational Biodiversity Genomics, Germany

    1 publications · 46 citations

    1

    h-index

  4. JL
    Jianjian Li

    Beijing Botanical Garden, China

    1 publications · 68 citations

    1

    h-index

  5. JG
    Jim Giovannoni

    Cornell University, United States

    1 publications · 68 citations

    1

    h-index

1–5 of 36

Institutions

32

  1. Center for Systems Biology Dresden

    Dresden, Germany

    2 h-index

    8 publications

    293 citations

  2. Max Planck Institute of Molecular Cell Biology and Genetics

    Dresden, Germany

    2 h-index

    8 publications

    293 citations

  3. Max Planck Institute for the Physics of Complex Systems

    Dresden, Germany

    2 h-index

    7 publications

    247 citations

  4. Beijing Botanical Garden

    Beijing, China

    1 h-index

    1 publications

    68 citations

  5. Cornell University

    Ithaca, United States

    1 h-index

    2 publications

    136 citations

  6. Institut de Biologia Evolutiva

    Barcelona, Spain

    1 h-index

    1 publications

    88 citations

  7. Pennsylvania State University

    State College, United States

    1 h-index

    1 publications

    88 citations

  8. Senckenberg Research Institute and Natural History Museum Frankfurt/M

    Frankfurt am Main, Germany

    1 h-index

    2 publications

    92 citations

1–8 of 32

Venues

  1. Molecular Biology and Evolution

    MBE · 2 publications · 109 citations

    2

    h-index

  2. 1

    h-index

  3. Biochemistry

    1 publications · 125 citations

    1

    h-index

  4. Cell Reports

    1 publications · 46 citations

    1

    h-index

  5. Nature Communications

    1 publications · 68 citations

    1

    h-index

1–5