Concepedia

Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity

Xiaoling Xie, Daniel Baird, Kimberly Elizabeth Bowen, Vladimı́r Čápka, Jinyun Chen, Gregg Chenail, YoungShin Cho, Julia Dooley, Ali Farsidjani, Pascal D. Fortin,

Structure · 2017 · 66 citations · 18 references

DOI

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18

<i>IDH1</i>and<i>IDH2</i>Mutations in Gliomas

Hai Yan, D. Williams Parsons, Genglin Jin et al. · New England Journal of Medicine · 2009 · 5.9K citations · Full text

, , +16

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

Lenny Dang, David W. White, Bryson D. Bennett et al. · Nature · 2009 · 4.1K citations · Full text

, , +10

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

Patrick S. Ward, Jay Patel, David R. Wise et al. · Cancer Cell · 2010 · 2K citations · Full text

, , +12

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Christian M. Metallo, Paulo A. Gameiro, Eric L. Bell et al. · Nature · 2011 · 1.8K citations · Full text

, , +17

Reductive carboxylation supports growth in tumour cells with defective mitochondria

Andrew R. Mullen, William W. Wheaton, Eunsook S. Jin et al. · Nature · 2011 · 1.3K citations · Full text

, , +12