Pascal D. Fortin

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan et al. · Nature · 2016 · 893 citations

Cancer Research, Allosteric Inhibition, Signal Transduction +12

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen et al. · Journal of Medicinal Chemistry · 2016 · 284 citations · Full text

Allosteric Inhibition, Drug Target, Shp2 Inhibition +20

High-Throughput Screening Identifies Inhibitors of the SARS Coronavirus Main Proteinase

Jan Blanchard, Nadine H. Elowe, Carly Huitema et al. · Chemistry & Biology · 2004 · 213 citations · Full text

Systems Biology, Viral Diagnostics, Antiviral Drug Development +7

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer

Matthew J. LaMarche, Michael Acker, Andreea Argintaru et al. · Journal of Medicinal Chemistry · 2020 · 207 citations · Full text

The Mechanism-based Inactivation of 2,3-Dihydroxybiphenyl 1,2-Dioxygenase by Catecholic Substrates

Frédéric H. Vaillancourt, Geneviève Labbé, Nathalie M. Drouin et al. · Journal of Biological Chemistry · 2002 · 124 citations · Full text