Pascal D. Fortin - Concepedia

Concepedia

Author

Pascal D. Fortin

University of British Columbia ORCID

Also Known As

Fortin, Pascal, P.D. Fortin, Pascal D. Fortin, Pascal Fortin, Pascal D. Fortin

81

Publications

2.9K

Citations

23

H-Index

43

Concepts

All Affiliations

University of British Columbia Harvard University Université Laval Novartis (United States)Purdue University West Lafayette

PD

About

Pascal D. Fortin is an author at University of British Columbia specializing in natural sciences, biochemistry, and medicine.

Top Concepts

#	Concept	H-Index	Publications	Citations
1	Natural Sciences	11	11	813
2	Biochemistry	11	11	775
3	Medicine	9	9	1.8K
4	Engineering	4	4	137
5	Biomolecular Engineering	1	1	60

Pascal D. Fortin

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27

Publications

2.9K

Citations

23

H-Index

	Year	Citations
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases Ying-Nan P. Chen, Matthew J. LaMarche, Ho Man Chan, Nature Cancer ResearchAllosteric InhibitionSignal TransductionSignaling PathwayMedicine	2016	893
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor Jorge Fortanet, Christine Hiu-Tung Chen, Ying-Nan P. Chen, Journal of Medicinal Chemistry Allosteric InhibitionDrug TargetShp2 InhibitionEfficacious Phosphatase InhibitorChemical Biology	2016	284
High-Throughput Screening Identifies Inhibitors of the SARS Coronavirus Main Proteinase Jan Blanchard, Nadine H. Elowe, Carly Huitema, Chemistry & Biology Systems BiologyViral DiagnosticsAntiviral Drug DevelopmentVirologyViral Structural Protein	2004	213
Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer Matthew J. LaMarche, Michael Acker, Andreea Argintaru, Journal of Medicinal Chemistry	2020	207
The Mechanism-based Inactivation of 2,3-Dihydroxybiphenyl 1,2-Dioxygenase by Catecholic Substrates Frédéric H. Vaillancourt, Geneviève Labbé, Nathalie M. Drouin, Journal of Biological Chemistry	2002	124
Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor Michael D. Shultz, Atwood K. Cheung, C.A. Kirby, Journal of Medicinal Chemistry Drug TargetSelective Tankyrase InhibitorsPharmacotherapyChemical BiologyPharmaceutical Chemistry	2013	122
Synthesis and Evaluation of Keto-Glutamine Analogues as Potent Inhibitors of Severe Acute Respiratory Syndrome 3CL<sup>pro</sup> Rajendra P. Jain, Hanna Pettersson, Jianmin Zhang, Journal of Medicinal Chemistry	2004	102
Molecular Basis for the Stabilization and Inhibition of 2,3-Dihydroxybiphenyl 1,2-Dioxygenase by t-Butanol Frédéric H. Vaillancourt, Seungil Han, Pascal D. Fortin, Journal of Biological Chemistry	1998	99
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia Andreas Varkaris, Ermira Pazolli, Hakan Günaydin, Cancer Discovery	2023	80
[1,2,4]Triazol-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: Antagonists of the Wnt Pathway That Inhibit Tankyrases 1 and 2 via Novel Adenosine Pocket Binding Michael D. Shultz, C.A. Kirby, Travis Stams, Journal of Medicinal Chemistry Drug TargetPharmacotherapyTumor BiologyMedicinal ChemistryAxin Stabilization	2012	69

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