Annals of Oncology · 2016 · 145 citations · 20 references
MedicineOncologyPharmacologyCancer PharmacologyDrug DiscoveryMolecular OncologyCancer PharmacogenomicsPersonalized Cancer TherapyPharmacodynamics Of Anticancer DrugsTargeted Cancer Therapy
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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.2K citations
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
Junko Murai, Shar-yin N. Huang, Benu Brata Das et al. · Cancer Research · 2012 · 2.2K citations · Full text
Medicine, Oncology, Pharmacology +17
The cellular thermal shift assay for evaluating drug target interactions in cells
Rozbeh Jafari, Helena Almqvist, Hanna Axelsson et al. · Nature Protocols · 2014 · 1.5K citations
Medicine, Cell Biology, Pharmacology +13
Tracking cancer drugs in living cells by thermal profiling of the proteome
Mikhail M. Savitski, Friedrich Reinhard, Holger Franken et al. · Science · 2014 · 1.2K citations
Pharmacy, Biochemistry, Oncology +17
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Helge Gad, Tobias Koolmeister, Ann‐Sofie Jemth et al. · Nature · 2014 · 529 citations