Christina Kalderén

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

Helge Gad, Tobias Koolmeister, Ann‐Sofie Jemth et al. · Nature · 2014 · 529 citations

Medicine, Cancer Biology, Oncology +4

Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Torkild Visnes, Armando Cázares‐Körner, Wenjing Hao et al. · Science · 2018 · 233 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Validation and development of MTH1 inhibitors for treatment of cancer

Ulrika Warpman Berglund, Kumar Sanjiv, Helge Gad et al. · Annals of Oncology · 2016 · 145 citations · Full text

Medicine, Oncology, Pharmacology +7

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Nadilly Bonagas, Nina Gustafsson, Martin Henriksson et al. · Nature Cancer · 2022 · 105 citations · Full text

Life Sciences, Molecular Biology, Oncology +16

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model

Lloyd Tanner, Andrew Single, Ravi K. V. Bhongir et al. · Nature Communications · 2023 · 105 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +12