Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation

Torkild Visnes, Armando Cázares‐Körner, Wenjing Hao, +37

Science

Validation and development of MTH1 inhibitors for treatment of cancer

Ulrika Warpman Berglund, Kumar Sanjiv, Helge Gad, +44

Annals of Oncology

OncologyMedicinePathologyAnti-cancer AgentMetronomic Chemotherapy +5

Mitochondrial base excision repair of uracil and AP sites takes place by single-nucleotide insertion and long-patch DNA synthesis

Mansour Akbari, Torkild Visnes, Hans E. Krokan, +1

DNA repair

Genome InstabilityDnaMitochondrial BiogenesisMitochondrial FunctionLong-patch Dna Synthesis +7

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

Henrik Sahlin Pettersen, Torkild Visnes, Cathrine Broberg Vågbø, +5

Nucleic Acids Research

The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions

Manuel Luís Orta, Andreas Höglund, José Manuel Calderón‐Montaño, +7

Nucleic Acids Research

AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature

Henrik Sahlin Pettersen, Anastasia Galashevskaya, Berit Doseth, +9

DNA repair

Lymphoid NeoplasiaOncogenic AgentGenomic UracilMalignant Blood DisorderImmunology +11

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

Maurice Michel, Carlos Benitéz‐Buelga, Patricia A. Calvo, +54

Science

Dna DamageMolecular BiologySmall-molecule ActivationRedox BiologyOxidative Stress +17

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress

Torkild Visnes, Carlos Benitéz‐Buelga, Armando Cázares‐Körner, +43

Nucleic Acids Research

Uracil-DNA Glycosylase in Base Excision Repair and Adaptive Immunity

Berit Doseth, Torkild Visnes, Anders Wallenius, +8

Journal of Biological Chemistry

Discovery of the First Potent and Selective Inhibitors of Human dCTP Pyrophosphatase 1

Sabin Llona‐Minguez, Andreas Höglund, Sylvain A. Jacques, +26

Journal of Medicinal Chemistry

Drug TargetSelective InhibitorsChemical BiologyCancer BiologyTumor Biology +19