Bioorganic & Medicinal Chemistry Letters · 2011 · 56 citations · 15 references
MedicineMedicinal ChemistryPharmacologyCancer PharmacologyMolecular PharmacologyStructure-activity RelationshipsEnzyme InhibitionMolecular DockingStructure-activity Relationship AnalysisTyrosine Kinase InhibitorsActivity RelationshipsB-raf InhibitorsMacrocyclic InhibitorsPyrazole ChemistryPyridazine ChemistrySequence - Activity Relationships
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Mutations of the BRAF gene in human cancer
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Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
Gideon Bollag, Peter Hirth, James Tsai et al. · Nature · 2010 · 1.8K citations
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