Nature Methods · 2014 · 838 citations · 20 references
Life SciencesGeneticsMolecular BiologyGenetic EngineeringGenome EditingGenome EngineeringCrispr-based EngineeringCrispr-cas SystemsGuide Rna DesignOff-target EffectsTarget Site SelectionTherapeutic Genome EditingCas Nuclease SpecificityCrispr-based Genome EngineeringCrispr-cas Genome EditingCrispr-cas Target CleavageCrispr-cas9 Genome EditingCrispr-cas9-mediated RepairNickase-cas9 Variants
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