A conditional knockout resource for the genome-wide study of mouse gene function

William C. Skarnes, Barry P. Rosen, Anthony P. West, +15

Nature

Knockout MouseFunctional GenomicsGeneticsGenome-wide StudyGene Characterization +11

Netrin-1 Is Required for Commissural Axon Guidance in the Developing Vertebrate Nervous System

Tito Serafini, Sophia A. Colamarino, E. David Leonardo, +4

Cell

NeuroregenerationDevelopmental BiologyNeuroanatomyCommissural Axon GuidanceNeuroscience +7

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects

Bin Shen, Jun Zhang, Jiankui Zhou, +7

Nature Methods

Crispr-cas9 NickaseGeneticsMolecular BiologyGenetic EngineeringGene Editing +5

Functional analysis of secreted and transmembrane proteins critical to mouse development

Kevin J. Mitchell, Kathy Pinson, Olivia Kelly, +13

Nature Genetics

Protein SecretionProtein FunctionSignal TransductionDevelopmental BiologyTransmembrane Proteins +9

Defining brain wiring patterns and mechanisms through gene trapping in mice

Philip A. Leighton, Kevin J. Mitchell, Lisa V. Goodrich, +5

Nature

Developmental BiologyNeurophysiologyBrain MechanismBrain Wiring PatternsSocial Sciences +9

Agouti C57BL/6N embryonic stem cells for mouse genetic resources

Stephen J. Pettitt, Qi Liang, Xin Y. Rairdan, +6

Nature Methods

Developmental BiologyMedicineStem Cell ResearchStem Cell BiologyStem Cells +3

A reference human induced pluripotent stem cell line for large-scale collaborative studies

Caroline B. Pantazis, Andrian Yang, Erika Lara, +92

Cell stem cell

WGE: a CRISPR database for genome engineering

Alex Hodgkins, Anna Farne, Sajith Perera, +4

Bioinformatics

glypican-3 Controls Cellular Responses to Bmp4 in Limb Patterning and Skeletal Development

Stephenie Paine‐Saunders, Beth L. Viviano, Joel Zupicich, +2

Developmental Biology

Limb PatterningSclerostinDevelopmental BiologyBone Morphogenic ProteinSkeletal Muscle +9

A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage

Xueqing Zou, Gene Ching Chiek Koh, Arjun S. Nanda, +98

Nature Cancer

Genome InstabilityMedicineGeneticsNatural SciencesMolecular Biology +9