A conditional knockout resource for the genome-wide study of mouse gene function

William C. Skarnes, Barry P. Rosen, Anthony P. West, +15

Nature

Knockout MouseFunctional GenomicsGeneticsGenome-wide StudyGene Characterization +11

Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects

Bin Shen, Jun Zhang, Jiankui Zhou, +7

Nature Methods

Crispr-cas9 NickaseGeneticsMolecular BiologyGenetic EngineeringGene Editing +5

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

Jacqueline K. White, Anna-Karin Gerdin, Natasha A. Karp, +122

Cell

Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis

Siddhartha Kar, Pedro M. Quirós, Muxin Gu, +11

Nature Genetics

The mammalian gene function resource: the international knockout mouse consortium

Allan Bradley, Konstantinos Anastassiadis, A. Ayadi, +76

Mammalian Genome

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, +30

Nucleic Acids Research

WGE: a CRISPR database for genome engineering

Alex Hodgkins, Anna Farne, Sajith Perera, +4

Bioinformatics

Large-scale sequencing identifies multiple genes and rare variants associated with Crohn’s disease susceptibility

Aleksejs Sazonovs, Christine Stevens, Guhan Venkataraman, +114

Nature Genetics

Genome-wide Association StudyDisease SusceptibilityAutoimmune DiseaseRare VariantsImmunology +6

BioMart Central Portal: an open database network for the biological community

Jonathan M. Guberman, Jing Ai, Olivier Arnaiz, +58

Database

UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs

Malgorzata Gozdecka, Eshwar Meduri, Milena Mazan, +24

Nature Genetics

Hematological MalignancyChromatinSystems BiologyNoncatalytic Inverse RegulationGata Programs +7