Concepedia

Design, synthesis, and biological evaluation of novel human 5′-deoxy-5′-methylthioadenosine phosphorylase (MTAP) substrates

Pei‐Pei Kung, Luke R. Zehnder, Jerry Meng, Stanley Kupchinsky, Donald J. Skalitzky, M. Catherine Johnson, Karen A. Maegley, Anne Ekker, Leslie A. Kuhn, Peter W. Rose,

Bioorganic & Medicinal Chemistry Letters · 2005 · 21 citations · 18 references

DOI

Concepts

References

18

Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

Andrew M. Kawasaki, Martin D. Casper, Susan M. Freier et al. · Journal of Medicinal Chemistry · 1993 · 436 citations

, , +16

Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers.

Tsutomu Nobori, K Takabayashi, Phuoc T. Tran et al. · Proceedings of the National Academy of Sciences · 1996 · 114 citations

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Enzymic capacities of purine de Novo and salvage pathways for nucleotide synthesis in normal and neoplastic tissues.

Yutaka Natsumeda, Noémi Prajda, John P. Donohue et al. · PubMed · 1984 · 101 citations

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Dependence of adenine production upon polyamine synthesis in cultured human lymphoblasts

Naoyuki Kamatani, Dennis A. Carson · Biochimica et Biophysica Acta (BBA) - General Subjects · 1981 · 100 citations

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The structure of human 5′-deoxy-5′-methylthioadenosine phosphorylase at 1.7 Å resolution provides insights into substrate binding and catalysis

T.C. Appleby, Mark D. Erion, S.E. Ealick · Structure · 1999 · 82 citations · Full text

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