Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

The serial cultivation of human diploid cell strains

Leonard Hayflick, Paul S. Moorhead · Experimental Cell Research · 1961 · 8.3K citations

Human Cell, Cell Division, Genetics +5

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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Regenerative Medicine, Cell Lineage, Crypt-villus Structures +9

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker, Johan H. van Es, Jeroen Kuipers et al. · Nature · 2007 · 5.6K citations

Cell Lineage, Cell Specialization, Marker Gene Lgr5 +10

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

Toshiro Sato, Daniel E. Stange, Marc Ferrante et al. · Gastroenterology · 2011 · 3.7K citations · Full text

Gastrointestinal Oncology, Medicine, Gastroenterology +7

‘Green mice’ as a source of ubiquitous green cells

Masaru Okabe, Masahito Ikawa, Katsuya Kominami et al. · FEBS Letters · 1997 · 2.6K citations

Biology, Xenotransplantation, Bioluminescence +13