Tomohiro Mizutani

Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli

Cayetano Pleguezuelos‐Manzano, Jens Puschhof, Axel Rosendahl Huber et al. · Nature · 2020 · 1.1K citations · Full text

Medicine, Pathogenesis, Colorectal Cancer +8

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

Shiro Yui, Tetsuya Nakamura, Toshiro Sato et al. · Nature Medicine · 2012 · 782 citations

Regenerative Medicine, Functional Engraftment, Developmental Biology +9

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

Jarno Drost, Ruben van Boxtel, Francis Blokzijl et al. · Science · 2017 · 454 citations · Full text

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation

Yong‐Hee Cho, Eun Ji Ro, Jeong-Su Yoon et al. · Nature Communications · 2020 · 327 citations · Full text

Small intestinal stem cell identity is maintained with functional Paneth cells in heterotopically grafted epithelium onto the colon

Masayoshi Fukuda, Tomohiro Mizutani, Wakana Mochizuki et al. · Genes & Development · 2014 · 179 citations · Full text

Cell Therapy, Adult Stem Cell, Immunology +16