A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity

Norman Sachs, Joep de Ligt, Oded Kopper, +28

Cell

Breast OncologyOncologyEngineeringBiobankTumor Heterogeneity +9

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Meritxell Huch, Helmuth Gehart, Ruben van Boxtel, +20

Cell

Enormous Replication PotentialAdult Stem CellExpanded CellsOrgan DevelopmentCholangiopathies +26

Tissue-specific mutation accumulation in human adult stem cells during life

Francis Blokzijl, Joep de Ligt, Myrthe Jager, +25

Nature

Embryonic Stem CellDevelopmental BiologyMedicineGeneticsTissue-specific Mutation Accumulation +7

MutationalPatterns: comprehensive genome-wide analysis of mutational processes

Francis Blokzijl, Roel Janssen, Ruben van Boxtel, +1

Genome Medicine

Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer

Jarno Drost, Ruben van Boxtel, Francis Blokzijl, +11

Science

Mutational Landscape and Patterns of Clonal Evolution in Relapsed Pediatric Acute Lymphoblastic Leukemia

Esmé Waanders, Zhaohui Gu, Stephanie M. Dobson, +40

Blood Cancer Discovery

Genomic landscape of rat strain and substrain variation

Roel Hermsen, Joep de Ligt, Wim Spee, +13

BMC Genomics

Deficiency of nucleotide excision repair is associated with mutational signature observed in cancer

Myrthe Jager, Francis Blokzijl, Ewart Kuijk, +11

Genome Research

Measuring mutation accumulation in single human adult stem cells by whole-genome sequencing of organoid cultures

Myrthe Jager, Francis Blokzijl, Valentina Sasselli, +6

Nature Protocols

Whole-genome SequencingHuman CellMutation AccumulationSingle Cell SequencingOrganoid Cultures +11

Generation and characterization of rat liver stem cell lines and their engraftment in a rat model of liver failure

Ewart Kuijk, Shauna Rasmussen, Francis Blokzijl, +7

Scientific Reports