Concepedia

Intestinal Stem Cells

Intestinal Stem Cells is a type of somatic stem cell resident in the crypts of Lieberkühn that continuously self-renews and gives rise to all differentiated epithelial lineages of the intestinal lining, thereby maintaining the integrity and functionality of the intestinal barrier.

1.5K

Publications

154.4K

Citations

8.7K

Authors

1.7K

Institutions

Publications per year

2017–2026

751

Variants

Iscs

Parents

Publications

1.5K

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker, Johan H. van Es, Jeroen Kuipers et al. · Nature · 2007 · 5.7K citations

, , +16

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Toshiro Sato, Johan H. van Es, Hugo J.G. Snippert et al. · Nature · 2010 · 2.5K citations

, , +15

Crypt stem cells as the cells-of-origin of intestinal cancer

Nick Barker, Rachel A. Ridgway, Johan H. van Es et al. · Nature · 2008 · 2.2K citations

, , +14

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

Hugo J.G. Snippert, Laurens G. van der Flier, Toshiro Sato et al. · Cell · 2010 · 2K citations · Full text

, , +16

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

Vladimír Kořínek, Nick Barker, Petra Moerer et al. · Nature Genetics · 1998 · 1.6K citations

, , +14

1–5 of 1.5K

Authors

8.7K

  1. HC
    Hans Clevers

    Hubrecht Institute for Developmental Biology and Stem Cell Research, Netherlands

    72 publications · 33.8K citations

    60

    h-index

  2. OJ
    Owen J. Sansom

    Cancer Research UK Scotland Institute, United Kingdom

    28 publications · 6.2K citations

    25

    h-index

  3. NB
    Nick Barker

    Hubrecht Institute for Developmental Biology and Stem Cell Research, Netherlands

    24 publications · 18.6K citations

    24

    h-index

  4. JH
    Johan H. van Es

    Hubrecht Institute for Developmental Biology and Stem Cell Research, Netherlands

    25 publications · 18.7K citations

    23

    h-index

  5. ST
    Scott T. Magness

    University of North Carolina at Chapel Hill, United States

    27 publications · 3.5K citations

    22

    h-index

1–5 of 8.7K

Institutions

1.7K

  1. Hubrecht Institute for Developmental Biology and Stem Cell Research

    Utrecht, Netherlands

    52 h-index

    229 publications

    174.3K citations

  2. University Medical Center Utrecht

    Utrecht, The Netherlands

    48 h-index

    269 publications

    117.8K citations

  3. Harvard University

    Cambridge, United States

    48 h-index

    316 publications

    46.3K citations

  4. Howard Hughes Medical Institute

    Chevy Chase, United States

    36 h-index

    83 publications

    21.1K citations

  5. University of North Carolina at Chapel Hill

    Chapel Hill, United States

    35 h-index

    209 publications

    18.9K citations

  6. Washington University in St. Louis

    St Louis, United States

    34 h-index

    172 publications

    31.8K citations

  7. Centre National de la Recherche Scientifique

    Paris, France

    30 h-index

    175 publications

    14.9K citations

  8. University of Cambridge

    Cambridge, United Kingdom

    28 h-index

    87 publications

    12.4K citations

1–8 of 1.7K

Venues

  1. Nature Communications

    63 publications · 5K citations

    44

    h-index

  2. Cell stem cell

    44 publications · 9.4K citations

    40

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 49 publications · 7.8K citations

    38

    h-index

  4. Cell Reports

    42 publications · 4.6K citations

    34

    h-index

  5. Nature

    31 publications · 23.1K citations

    31

    h-index

1–5