Concepedia

Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

Toshiro Sato, Johan H. van Es, Hugo J.G. Snippert, Daniel E. Stange, Robert G. Vries, Maaike van den Born, Nick Barker, Noah F. Shroyer, Marc van de Wetering, Hans Clevers

Nature · 2010 · 2.5K citations · 27 references

DOI

Concepts

References

27

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert et al. · Nature · 2009 · 7.2K citations

, , +14

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker, Johan H. van Es, Jeroen Kuipers et al. · Nature · 2007 · 5.7K citations

, , +16

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

Marc van de Wetering, Elena Sancho, Cornelis L. Verweij et al. · Cell · 2002 · 2K citations · Full text

, , +16

Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells

Hugo J.G. Snippert, Laurens G. van der Flier, Toshiro Sato et al. · Cell · 2010 · 2K citations · Full text

, , +16

A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse

Amy Moser, Henry C. Pitot, William F. Dove · Science · 1990 · 1.6K citations

, , +17